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Abstract Ultrasonically-sculpted gradient-index optical waveguides enable non-invasive light confinement inside scattering media. The confinement level strongly depends on ultrasound parameters (e.g., amplitude, frequency), and medium optical properties (e.g., extinction coefficient). We develop a physically-accurate simulator, and use it to quantify these dependencies for a radially-symmetric virtual optical waveguide. Our analysis provides insights for optimizing virtual optical waveguides for given applications. We leverage these insights to configure virtual optical waveguides that improve light confinement fourfold compared to previous configurations at five mean free paths. We show that virtual optical waveguides enhance light throughput by 50% compared to an ideal external lens, in a medium with bladder-like optical properties at one transport mean free path. We corroborate these simulation findings with real experiments: we demonstrate, for the first time, that virtual optical waveguides recycle scattered light, and enhance light throughput by 15% compared to an external lens at five transport mean free paths.